Significance of Preexisting Vector Immunity and Activation of Innate Responses for Adenoviral Vector-Based Therapy

An adenoviral (AdV)-based vector system is a promising platform for vaccine development and gene therapy applications. Administration of an AdV vector elicits robust innate immunity, leading to the development of humoral and cellular immune responses against the vector and the transgene antigen, if...

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Bibliographic Details
Main Authors: Wen-Chien Wang, Ekramy E. Sayedahmed, Suresh K. Mittal
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/14/12/2727