Engineering Vascularized Islet Macroencapsulation Devices: An in vitro Platform to Study Oxygen Transport in Perfused Immobilized Pancreatic Beta Cell Cultures

Engineering Vascularized Islet Macroencapsulation Devices: An in vitro Platform to Study Oxygen Transport in Perfused Immobilized Pancreatic Beta Cell Cultures

Islet encapsulation devices serve to deliver pancreatic beta cells to type 1 diabetic patients without the need for chronic immunosuppression. However, clinical translation is hampered by mass transport limitations causing graft hypoxia. This is exacerbated in devices relying only on passive diffusi...

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Bibliographic Details
Main Authors: Fernandez S. A., Champion K. S., Danielczak L., Gasparrini M., Paraskevas S., Leask R. L., Hoesli C. A.
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
type 1 diabetes
immobilized culture
artificial vascularization
oxygen mass transport
oxygen model
beta cells
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.884071/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.884071/full

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