ATRX dysfunction induces replication defects in primary mouse cells.

ATRX dysfunction induces replication defects in primary mouse cells.

The chromatin remodeling protein ATRX, which targets tandem repetitive DNA, has been shown to be required for expression of the alpha globin genes, for proliferation of a variety of cellular progenitors, for chromosome congression and for the maintenance of telomeres. Mutations in ATRX have recently...

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Bibliographic Details
Main Authors: David Clynes, Clare Jelinska, Barbara Xella, Helena Ayyub, Stephen Taylor, Matthew Mitson, Csanád Z Bachrati, Douglas R Higgs, Richard J Gibbons
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3961441?pdf=render

Internet

http://europepmc.org/articles/PMC3961441?pdf=render

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