Tradeoffs in alignment and assembly-based methods for structural variant detection with long-read sequencing data

Tradeoffs in alignment and assembly-based methods for structural variant detection with long-read sequencing data

Abstract Long-read sequencing offers long contiguous DNA fragments, facilitating diploid genome assembly and structural variant (SV) detection. Efficient and robust algorithms for SV identification are crucial with increasing data availability. Alignment-based methods, favored for their computationa...

Full description

Bibliographic Details
Main Authors: Yichen Henry Liu, Can Luo, Staunton G. Golding, Jacob B. Ioffe, Xin Maizie Zhou
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46614-z

Internet

https://doi.org/10.1038/s41467-024-46614-z

Similar Items