Tradeoffs in alignment and assembly-based methods for structural variant detection with long-read sequencing data

Tradeoffs in alignment and assembly-based methods for structural variant detection with long-read sequencing data

Abstract Long-read sequencing offers long contiguous DNA fragments, facilitating diploid genome assembly and structural variant (SV) detection. Efficient and robust algorithms for SV identification are crucial with increasing data availability. Alignment-based methods, favored for their computationa...

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Bibliographic Details
Main Authors: Yichen Henry Liu, Can Luo, Staunton G. Golding, Jacob B. Ioffe, Xin Maizie Zhou
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46614-z

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