Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer’s disease, whereas amyloid deposition does not

Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer’s disease, whereas amyloid deposition does not

Abstract Background The underlying mechanism of brain glucose hypometabolism, an invariant neurodegenerative feature that tightly correlates with cognitive impairment and disease progression of Alzheimer’s disease (AD), remains elusive. Methods Positron emission tomography with 2-[18F]fluoro-2-deoxy...

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Bibliographic Details
Main Authors: Shaoming Sang, Xiaoli Pan, Zhichun Chen, Fan Zeng, Shumei Pan, Huimin Liu, Lirong Jin, Guoqiang Fei, Changpeng Wang, Shuhua Ren, Fangyang Jiao, Weiqi Bao, Weiyan Zhou, Yihui Guan, Yiqiu Zhang, Hongcheng Shi, Yanjiang Wang, Xiang Yu, Yun Wang, Chunjiu Zhong
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Brain glucose metabolism
Thiamine diphosphate
Amyloid-β
Position emission tomography
Online Access:http://link.springer.com/article/10.1186/s13195-018-0354-2

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http://link.springer.com/article/10.1186/s13195-018-0354-2

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