Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer.

Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer.

Epigenetic alterations have been implicated in the pathogenesis of solid tumors, however, proto-oncogenes activated by promoter demethylation have been sporadically reported. We used an integrative method to analyze expression in primary head and neck squamous cell carcinoma (HNSCC) and pharmacologi...

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Bibliographic Details
Main Authors: Ian M Smith, Chad A Glazer, Suhail K Mithani, Michael F Ochs, Wenyue Sun, Sheetal Bhan, Alexander Vostrov, Ziedulla Abdullaev, Victor Lobanenkov, Andrew Gray, Chunyan Liu, Steven S Chang, Kimberly L Ostrow, William H Westra, Shahnaz Begum, Mousumi Dhara, Joseph Califano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2654921?pdf=render

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http://europepmc.org/articles/PMC2654921?pdf=render

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