The lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope binding

The lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope binding

ABSTRACTLamins A/C are nuclear intermediate filament proteins that are involved in diverse cellular mechanical and biochemical functions. Here, we report that recognition of Lamins A/C by a commonly used antibody (JOL-2) that binds the Lamin A/C Ig-fold and other antibodies targeting similar epitope...

Full description

Bibliographic Details
Main Authors: Melanie Wallace, Gregory R. Fedorchak, Richa Agrawal, Rachel M. Gilbert, Jineet Patel, Sangwoo Park, Matthew Paszek, Jan Lammerding
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Nucleus
Subjects:
Lamins
immunofluorescence
Ig-fold
cell density
cell spreading
mechanobiology
Online Access:https://www.tandfonline.com/doi/10.1080/19491034.2023.2180206

Internet

https://www.tandfonline.com/doi/10.1080/19491034.2023.2180206

Similar Items