A TRAF-like E3 ubiquitin ligase TrafE coordinates ESCRT and autophagy in endolysosomal damage response and cell-autonomous immunity to Mycobacterium marinum

A TRAF-like E3 ubiquitin ligase TrafE coordinates ESCRT and autophagy in endolysosomal damage response and cell-autonomous immunity to Mycobacterium marinum

Cells are perpetually challenged by pathogens, protein aggregates or chemicals, that induce plasma membrane or endolysosomal compartments damage. This severe stress is recognised and controlled by the endosomal sorting complex required for transport (ESCRT) and the autophagy machineries, which are r...

Full description

Bibliographic Details
Main Authors: Lyudmil Raykov, Manon Mottet, Jahn Nitschke, Thierry Soldati
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-04-01
Series:eLife
Subjects:
host-pathogen interaction
Mycobacterium marinum
membrane damage
ESCRT
autophagy
infection
Online Access:https://elifesciences.org/articles/85727

Internet

https://elifesciences.org/articles/85727

Similar Items