Regional and age-dependent changes in ubiquitination in cellular and mouse models of spinocerebellar ataxia type 3

Regional and age-dependent changes in ubiquitination in cellular and mouse models of spinocerebellar ataxia type 3

Spinocerebellar ataxia type 3 (SCA3), also known as Machado–Joseph disease, is the most common dominantly inherited ataxia. SCA3 is caused by a CAG repeat expansion in the ATXN3 gene that encodes an expanded tract of polyglutamine in the disease protein ataxin-3 (ATXN3). As a deubiquitinating enzyme...

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Bibliographic Details
Main Authors: Haiyang Luo, Sokol V. Todi, Henry L. Paulson, Maria do Carmo Costa
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Machado-Joseph disease
polyglutamine
CAG repeat
neurodegeneration
posttranslational modification
protein homeostasis
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1154203/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1154203/full

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