Distinct transcriptomic features are associated with transitional and mature B-cell populations in the mouse spleen

Distinct transcriptomic features are associated with transitional and mature B-cell populations in the mouse spleen

Splenic transitional B-cells (T1 and T2) are selected to avoid self-reactivity and to safeguard against autoimmunity, then differentiate into mature follicular (FO-I and FO-II) and marginal zone (MZ) subsets. Transcriptomic analysis by RNA-seq of the five B-cell subsets revealed T1 cell signature ge...

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Bibliographic Details
Main Authors: Eden eKleiman, Daria eSalyakina, Magali eDe Heusch, Kristen L Hoek, Joan M Llanes, Iris eCastro, Jacqueline A Wright, Emily S Clark, Derek Michael Dykxhoorn, Akiko eTakeda, Enrico eCapobianco, Jean-Christophe eRenauld, Wasif N Khan
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Immunology
Subjects:
Autoimmunity
STAT Transcription Factors
Transcription Factors
Transcriptome
PI3K
B cell development
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00030/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00030/full

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