13C-Metabolic flux analysis detected a hyperoxemia-induced reduction of tricarboxylic acid cycle metabolism in granulocytes during two models of porcine acute subdural hematoma and hemorrhagic shock

13C-Metabolic flux analysis detected a hyperoxemia-induced reduction of tricarboxylic acid cycle metabolism in granulocytes during two models of porcine acute subdural hematoma and hemorrhagic shock

IntroductionSupplementation with increased inspired oxygen fractions has been suggested to alleviate the harmful effects of tissue hypoxia during hemorrhagic shock (HS) and traumatic brain injury. However, the utility of therapeutic hyperoxia in critical care is disputed to this day as controversial...

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Bibliographic Details
Main Authors: Eva-Maria Wolfschmitt, Josef Albert Vogt, Melanie Hogg, Ulrich Wachter, Nicole Stadler, Thomas Kapapa, Thomas Datzmann, David Alexander Christian Messerer, Andrea Hoffmann, Michael Gröger, Franziska Münz, René Mathieu, Simon Mayer, Tamara Merz, Pierre Asfar, Enrico Calzia, Peter Radermacher, Fabian Zink
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
Bayesian modeling
glucose metabolism
glutamine utilization
hyperoxia
immunometabolism
mass isotopomer distribution
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1319986/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1319986/full

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