A senescence restriction point acting on chromatin integrates oncogenic signals

A senescence restriction point acting on chromatin integrates oncogenic signals

Summary: We identify a senescence restriction point (SeRP) as a critical event for cells to commit to senescence. The SeRP integrates the intensity and duration of oncogenic stress, keeps a memory of previous stresses, and combines oncogenic signals acting on different pathways by modulating chromat...

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Bibliographic Details
Main Authors: Stéphane Lopes-Paciencia, Véronique Bourdeau, Marie-Camille Rowell, Davoud Amirimehr, Jordan Guillon, Paloma Kalegari, Arnab Barua, Vincent Quoc-Huy Trinh, Feryel Azzi, Simon Turcotte, Adrian Serohijos, Gerardo Ferbeyre
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724003723

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http://www.sciencedirect.com/science/article/pii/S2211124724003723

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