Simvastatin Prevents Liver Microthrombosis and Sepsis Induced Coagulopathy in a Rat Model of Endotoxemia

Simvastatin Prevents Liver Microthrombosis and Sepsis Induced Coagulopathy in a Rat Model of Endotoxemia

Background: Endotoxemia causes endothelial dysfunction and microthrombosis, which are pathogenic mechanisms of coagulopathy and organ failure during sepsis. Simvastatin has potential anti-thrombotic effects on liver endothelial cells. We investigated the hemostatic changes induced by lipopolysacchar...

Full description

Bibliographic Details
Main Authors: Vincenzo La Mura, Nicoletta Gagliano, Francesca Arnaboldi, Patrizia Sartori, Patrizia Procacci, Luca Denti, Eleonora Liguori, Niccolò Bitto, Giuseppe Ristagno, Roberto Latini, Daniele Dondossola, Francesco Salerno, Armando Tripodi, Massimo Colombo, Flora Peyvandi
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
sepsis
sinusoidal endothelial cells
thrombomodulin
coagulation
Online Access:https://www.mdpi.com/2073-4409/11/7/1148

Internet

https://www.mdpi.com/2073-4409/11/7/1148

Similar Items