Protective role of the curcumin derivative, FM0807, in regulating JAK2/STAT3 and TGF-β1/SMAD2/3 signaling pathways in glomerular mesangial cells and renal function in db/db mice

Protective role of the curcumin derivative, FM0807, in regulating JAK2/STAT3 and TGF-β1/SMAD2/3 signaling pathways in glomerular mesangial cells and renal function in db/db mice

To determine the protective effects of FM0807 against diabetes-induced renal inflammation and fibrosis and the underlying mechanisms in vivo and in vitro. FM0807 was administered to db/db mice. Glomerular mesangial cells (HBZY-1) were cultured under high glucose conditions with or without FM0807. Ge...

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Bibliographic Details
Main Authors: Nanwen Zhang, Duoduo Lin, Honglin Wang, Ningning Zheng, Weipeng Lai, Liangyi Li, Jianhua Xu, Xiaole Chen
Format: Article
Language:English
Published: Compuscript Ltd 2024-06-01
Series:Acta Materia Medica
Subjects:
diabetic kidney disease
fm0807
inflammation
renal function
renal fibrosis
type 2 diabetes mellitus murine model
Online Access:https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0014

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https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0014

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