Methylglyoxal: a novel upstream regulator of DNA methylation

Methylglyoxal: a novel upstream regulator of DNA methylation

Abstract Background Aerobic glycolysis, also known as the Warburg effect, is predominantly upregulated in a variety of solid tumors, including breast cancer. We have previously reported that methylglyoxal (MG), a very reactive by-product of glycolysis, unexpectedly enhanced the metastatic potential...

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Bibliographic Details
Main Authors: Gaurav Dube, Assia Tiamiou, Martin Bizet, Yasmine Boumahd, Imène Gasmi, Rebekah Crake, Justine Bellier, Marie-Julie Nokin, Emilie Calonne, Rachel Deplus, Tom Wissocq, Olivier Peulen, Vincent Castronovo, François Fuks, Akeila Bellahcène
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Methylglyoxal
DNA methylation
Breast cancer
Tumor suppressor genes
Metastasis
Online Access:https://doi.org/10.1186/s13046-023-02637-w

Internet

https://doi.org/10.1186/s13046-023-02637-w

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