Disseminated medulloblastoma in a child with germline BRCA2 6174delT mutation and without Fanconi anemia

Disseminated medulloblastoma in a child with germline BRCA2 6174delT mutation and without Fanconi anemia

Medulloblastoma, the most common malignant brain tumor in children, occurs with increased frequency in individuals with Fanconi anemia who have biallelic germline mutations in BRCA2. We describe an 8 year old child who had disseminated anaplastic medulloblastoma and a deleterious heterozygous BRCA2...

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Bibliographic Details
Main Authors: Jingying eXu, Ashley Sloane Margol, Anju eShukla, Xiuhai eRen, Jonathan L Finlay, Mark D Krieger, Floyd H Gilles, Fergus J Couch, Meraj eAziz, Eric T Fung, Shahab eAsgharzadeh, Michael T Barrett, Anat eErdreich-Epstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Oncology
Subjects:
Fanconi Anemia
MYC
BRCA2 6174delT
Group 4 medulloblastoma
medulloblastoma cell lines
Recurrenct medulloblastoma
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00191/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00191/full

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