Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner

Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner

Abstract Background Metabolic reprogramming is one of the hallmarks of cancer cells. The pentose phosphate pathway (PPP), a branch of glycolysis, is an important metabolic pathway for the survival and biosynthesis of cancer cells. Transketolase (TKT) is a key enzyme in the non-oxidative phase of PPP...

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Bibliographic Details
Main Authors: Zhaoyu Qin, Chan Xiang, Fan Zhong, Yang Liu, Qiongzhu Dong, Kai Li, Wenhao Shi, Chen Ding, Lunxiu Qin, Fuchu He
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hepatocellular carcinoma
Pentose phosphate pathway
Transketolase
Nuclear localization
Non-metabolic function
Online Access:http://link.springer.com/article/10.1186/s13046-019-1131-1

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http://link.springer.com/article/10.1186/s13046-019-1131-1

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