Isolation, identification, structural elucidation, and toxicity prediction using (Q)-SAR models of two degradants: AQbD-driven LC method to determine the Roxadustat impurities

Isolation, identification, structural elucidation, and toxicity prediction using (Q)-SAR models of two degradants: AQbD-driven LC method to determine the Roxadustat impurities

ABSTRACT: Roxadustat (RDT) is the first orally administrated HIF-prolyl hydroxylase inhibitor drug used to treat anemia caused by chronic kidney disease. Two unknown degradants were detected in photolytic and oxidative stress conditions during the forced degradation study of RDT and isolated them us...

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Bibliographic Details
Main Authors: Srinivas Nakka, Naresh Kumar Katari, Siva Krishna Muchakayala, Sreekantha Babu Jonnalagadda, Surendra Babu Manabolu Surya
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Talanta Open
Subjects:
Roxadustat
QSAR models
Derek
Sarah
Structural elucidation
Analytical quality by design
Online Access:http://www.sciencedirect.com/science/article/pii/S2666831923000425

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http://www.sciencedirect.com/science/article/pii/S2666831923000425

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