Function, mechanism and drug discovery of ubiquitin and ubiquitin-like modification with multiomics profiling for cancer therapy

Function, mechanism and drug discovery of ubiquitin and ubiquitin-like modification with multiomics profiling for cancer therapy

Ubiquitin (Ub) and ubiquitin-like (Ubl) pathways are critical post-translational modifications that determine whether functional proteins are degraded or activated/inactivated. To date, >600 associated enzymes have been reported that comprise a hierarchical task network (e.g., E1–E2–E3 cascade en...

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Bibliographic Details
Main Authors: Yanyu Jiang, Shuaishuai Ni, Biying Xiao, Lijun Jia
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Ub and Ubl modifications
Ub-activating enzyme
Ub-conjugating enzyme
Ub ligase
Multiomics analyses
Drug discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523002812

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http://www.sciencedirect.com/science/article/pii/S2211383523002812

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