FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model

FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model

Amyloid-β (Aβ)-containing extracellular plaques and hyperphosphorylated tau-loaded intracellular neurofibrillary tangles are neuropathological hallmarks of Alzheimer's disease (AD). Although Aβ exerts neuropathogenic activity through tau, the mechanistic link between Aβ and tau pathology remain...

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Bibliographic Details
Main Authors: Tae-In Kam, Hyejin Park, Youngdae Gwon, Sungmin Song, Seo-Hyun Kim, Seo Won Moon, Dong-Gyu Jo, Yong-Keun Jung
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
Alzheimer
amyloid
tau
SHIP2
phosphoinositide
fc gamma receptor
Online Access:https://elifesciences.org/articles/18691

Internet

https://elifesciences.org/articles/18691

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