Differential expression of SDF-1 receptor CXCR4 in molecularly defined forms of inherited thrombocytopenias

Differential expression of SDF-1 receptor CXCR4 in molecularly defined forms of inherited thrombocytopenias

The SDF-1-CXCR4 axis plays an essential role in the regulation of platelet production, by directing megakaryocyte (MK) migration toward the vascular niche, thus allowing terminal maturation and proplatelet formation, and also regulates platelet function in an autocrine manner. Inherited thrombocytop...

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Bibliographic Details
Main Authors: Juan P. Salim, Ana C. Glembotsky, Paola R. Lev, Cecilia P. Marin Oyarzún, Nora P. Goette, Felisa C. Molinas, Rosana F. Marta, Paula G. Heller
Format: Article
Language:English
Published: Taylor & Francis Group 2017-08-01
Series:Platelets
Subjects:
cxcr4
inherited thrombocytopenias
sdf-1
Online Access:http://dx.doi.org/10.1080/09537104.2016.1254763

Internet

http://dx.doi.org/10.1080/09537104.2016.1254763

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