Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway

Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway

Objective: Osteoarthritis (OA) is a common disease with a complex pathology including mechanical load, inflammation, and metabolic factors. Chondrocyte ferroptosis contributes to OA progression. Because iron deposition is a major pathological event in ferroptosis, deferoxamine (DFO), an effective ir...

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Bibliographic Details
Main Authors: Zhou Guo, Jiamin Lin, Kai Sun, Jiayou Guo, Xudong Yao, Genchun Wang, Liangcai Hou, Jingting Xu, Jiachao Guo, Fengjing Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
osteoarthritis
chondrocytes
ferroptosis
deferoxamine
Nrf2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.791376/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.791376/full

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