Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation in mammalian nuclear genome
SET8 is post-translationally poly ADPribosylated by PARP1 on several lysine residues, leading to SET8 degradation via ubiquitylation and genome-wide aberrant H4K20 methylation.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-04241-8 |