Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation in mammalian nuclear genome
SET8 is post-translationally poly ADPribosylated by PARP1 on several lysine residues, leading to SET8 degradation via ubiquitylation and genome-wide aberrant H4K20 methylation.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-04241-8 |
| _version_ | 1811215930010632192 |
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| author | Pierre-Olivier Estève Sagnik Sen Udayakumar S. Vishnu Cristian Ruse Hang Gyeong Chin Sriharsa Pradhan |
| author_facet | Pierre-Olivier Estève Sagnik Sen Udayakumar S. Vishnu Cristian Ruse Hang Gyeong Chin Sriharsa Pradhan |
| author_sort | Pierre-Olivier Estève |
| collection | DOAJ |
| description | SET8 is post-translationally poly ADPribosylated by PARP1 on several lysine residues, leading to SET8 degradation via ubiquitylation and genome-wide aberrant H4K20 methylation. |
| first_indexed | 2024-04-12T06:31:37Z |
| format | Article |
| id | doaj.art-99363f409dd743ae9dcafbee136ff4b4 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-12T06:31:37Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-99363f409dd743ae9dcafbee136ff4b42022-12-22T03:44:01ZengNature PortfolioCommunications Biology2399-36422022-11-015111810.1038/s42003-022-04241-8Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation in mammalian nuclear genomePierre-Olivier Estève0Sagnik Sen1Udayakumar S. Vishnu2Cristian Ruse3Hang Gyeong Chin4Sriharsa Pradhan5New England Biolabs IncNew England Biolabs IncNew England Biolabs IncNew England Biolabs IncNew England Biolabs IncNew England Biolabs IncSET8 is post-translationally poly ADPribosylated by PARP1 on several lysine residues, leading to SET8 degradation via ubiquitylation and genome-wide aberrant H4K20 methylation.https://doi.org/10.1038/s42003-022-04241-8 |
| spellingShingle | Pierre-Olivier Estève Sagnik Sen Udayakumar S. Vishnu Cristian Ruse Hang Gyeong Chin Sriharsa Pradhan Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation in mammalian nuclear genome Communications Biology |
| title | Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation in mammalian nuclear genome |
| title_full | Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation in mammalian nuclear genome |
| title_fullStr | Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation in mammalian nuclear genome |
| title_full_unstemmed | Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation in mammalian nuclear genome |
| title_short | Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation in mammalian nuclear genome |
| title_sort | poly adp ribosylation of set8 leads to aberrant h4k20 methylation in mammalian nuclear genome |
| url | https://doi.org/10.1038/s42003-022-04241-8 |
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