Deleterious Interaction between the Neurosteroid (3α,5α)3-Hydroxypregnan-20-One (3α,5α-THP) and the Mu-Opioid System Activation during Forced Swim Stress in Rats

Deleterious Interaction between the Neurosteroid (3α,5α)3-Hydroxypregnan-20-One (3α,5α-THP) and the Mu-Opioid System Activation during Forced Swim Stress in Rats

The neurosteroid 3α,5α-THP is a potent GABA<sub>A</sub> receptor-positive modulator and its regulatory action on the HPA axis stress response has been reported in numerous preclinical and clinical studies. We previously demonstrated that 3α,5α-THP down-regulation of HPA axis activity dur...

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Bibliographic Details
Main Authors: Giorgia Boero, Minna H. McFarland, Ryan E. Tyler, Todd K. O’Buckley, Samantha L. Chéry, Donita L. Robinson, Joyce Besheer, A. Leslie Morrow
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Biomolecules
Subjects:
neurosteroids
behavior
stress
forced swim stress
3α,5α-THP
allopregnanolone
Online Access:https://www.mdpi.com/2218-273X/13/8/1205

Internet

https://www.mdpi.com/2218-273X/13/8/1205

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