The adjuvants dmLT and mmCT enhance humoral immune responses to a pneumococcal conjugate vaccine after both parenteral or mucosal immunization of neonatal mice

The adjuvants dmLT and mmCT enhance humoral immune responses to a pneumococcal conjugate vaccine after both parenteral or mucosal immunization of neonatal mice

Immaturity of the neonatal immune system contributes to increased susceptibility to infectious diseases and poor vaccine responses. Therefore, better strategies for early life vaccination are needed. Adjuvants can enhance the magnitude and duration of immune responses. In this study we assessed the...

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Bibliographic Details
Main Authors: Jenny Lorena Molina Estupiñan, Audur Anna Aradottir Pind, Poorya Foroutan Pajoohian, Ingileif Jonsdottir, Stefania P. Bjarnarson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
vaccination
neonates
adjuvants
mucosal immunization
antibodies
germinal center
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1078904/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1078904/full

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