Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response

Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response

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The objective of this study was to investigate whether a single defect in skin barrier function simulated by filaggrin silencing could induce Th2-predominant inflammation. Filaggrin gene expression was silenced in cultured normal human epidermal keratinocytes (NHEKs) using small hairpin RNA (shRNA,...

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Bibliographic Details
Main Authors: N.N. Dang, S.G. Pang, H.Y. Song, L.G. An, X.L. Ma
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2015-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Atopic dermatitis
T helper 2 cytokines
Filaggrin silencing
Pathogenesis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000100039&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000100039&lng=en&tlng=en

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