Activation of a Ductal-to-Endocrine Transdifferentiation Transcriptional Program in the Pancreatic Cancer Cell Line PANC-1 Is Controlled by RAC1 and RAC1b through Antagonistic Regulation of Stemness Factors

Activation of a Ductal-to-Endocrine Transdifferentiation Transcriptional Program in the Pancreatic Cancer Cell Line PANC-1 Is Controlled by RAC1 and RAC1b through Antagonistic Regulation of Stemness Factors

Epithelial–mesenchymal transition (EMT) is a driving force for tumor growth, metastatic spread, therapy resistance, and the generation of cancer stem cells (CSCs). However, the regained stem cell character may also be exploited for therapeutic conversion of aggressive tumor cells to benign, highly d...

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Bibliographic Details
Main Authors: Paula Marie Schmidtlein, Clara Volz, Alexander Hackel, Isabel Thürling, Darko Castven, Rüdiger Braun, Ulrich Friedrich Wellner, Björn Konukiewitz, Gabriela Riemekasten, Hendrik Lehnert, Jens-Uwe Marquardt, Hendrik Ungefroren
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
PANC-1
quasimesenchymal
ductal-to-endocrine transdifferentiation
pancreatic β cell
stemness
Online Access:https://www.mdpi.com/2072-6694/13/21/5541

Internet

https://www.mdpi.com/2072-6694/13/21/5541

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