Rearrangement in the Hypervariable Region of JC Polyomavirus Genomes Isolated from Patient Samples and Impact on Transcription Factor-Binding Sites and Disease Outcomes

Rearrangement in the Hypervariable Region of JC Polyomavirus Genomes Isolated from Patient Samples and Impact on Transcription Factor-Binding Sites and Disease Outcomes

JC polyomavirus (JCPyV) is the causative agent of the fatal, incurable, neurological disease, progressive multifocal leukoencephalopathy (PML). The virus is present in most of the adult population as a persistent, asymptotic infection in the kidneys. During immunosuppression, JCPyV reactivates and i...

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Bibliographic Details
Main Authors: Michael P. Wilczek, Aiden M. C. Pike, Sophie E. Craig, Melissa S. Maginnis, Benjamin L. King
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
JC polyomavirus
transcription factors
mutations
viral genome
PML
NCCR
Online Access:https://www.mdpi.com/1422-0067/23/10/5699

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https://www.mdpi.com/1422-0067/23/10/5699

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