Effects of dopamine D2/3 and opioid receptor antagonism on the trade-off between model-based and model-free behaviour in healthy volunteers

Effects of dopamine D2/3 and opioid receptor antagonism on the trade-off between model-based and model-free behaviour in healthy volunteers

Human behaviour requires flexible arbitration between actions we do out of habit and actions that are directed towards a specific goal. Drugs that target opioid and dopamine receptors are notorious for inducing maladaptive habitual drug consumption; yet, how the opioidergic and dopaminergic neurotra...

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Bibliographic Details
Main Authors: Nace Mikus, Sebastian Korb, Claudia Massaccesi, Christian Gausterer, Irene Graf, Matthäus Willeit, Christoph Eisenegger, Claus Lamm, Giorgia Silani, Christoph Mathys
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-12-01
Series:eLife
Subjects:
reinforcement learning
cognitive control
decision-making
Online Access:https://elifesciences.org/articles/79661

Internet

https://elifesciences.org/articles/79661

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