A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells

A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells

When replication forks encounter DNA lesions that cause polymerase stalling, a checkpoint pathway is activated. The ATR-dependent intra-S checkpoint pathway mediates detection and processing of sites of replication fork stalling to maintain genomic integrity. Several factors involved in the global c...

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Bibliographic Details
Main Authors: Sana Ahmed-Seghir, Manisha Jalan, Helen E Grimsley, Aman Sharma, Shyam Twayana, Settapong T Kosiyatrakul, Christopher Thompson, Carl L Schildkraut, Simon N Powell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-08-01
Series:eLife
Subjects:
DNA damage
Tus-TerB
DNA replication
replication stress
genomic instability
ATR
Online Access:https://elifesciences.org/articles/87357

Internet

https://elifesciences.org/articles/87357

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