Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA class I) allotypes

The extreme polymorphisms of human leukocyte antigen class I (HLA class I) proteins enable the presentation of diverse peptides to cytotoxic T lymphocytes. The canonical endoplasmic reticulum (ER) HLA class I assembly pathway enables presentation of cytosolic peptides, but effective intracellular su...

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Bibliographic Details
Main Authors: Eli Olson, Theadora Ceccarelli, Malini Raghavan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-02-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/79144