Engineered geranyl diphosphate methyltransferase produces 2-methyl-dimethylallyl diphosphate as a noncanonical C6 unit for terpenoid biosynthesis

Engineered geranyl diphosphate methyltransferase produces 2-methyl-dimethylallyl diphosphate as a noncanonical C6 unit for terpenoid biosynthesis

Terpenoids constitute the largest class of natural products with complex structures, essential functions, and versatile applications. Creation of new building blocks beyond the conventional five-carbon (C5) units, dimethylallyl diphosphate (DMAPP) and isopentenyl diphosphate, expands significantly t...

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Bibliographic Details
Main Authors: Chen-Yang Xia, Bo-Wen Lu, Ji-Yun Cui, Bai-Yang Wang, Yue-Yang Sun, Fei Gan
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-03-01
Series:Synthetic and Systems Biotechnology
Subjects:
Protein engineering
Terpenoid biosynthesis
Methyltransferase
Noncanonical building block
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X22001211

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http://www.sciencedirect.com/science/article/pii/S2405805X22001211

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