Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence

Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence

Drug resistance prevents the successful treatment of HIV-positive individuals by decreasing viral sensitivity to a drug or a class of drugs. In addition to transmitted resistant viruses, treatment-naïve individuals can be confronted with the problem of drug resistance through de novo emergence of su...

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Bibliographic Details
Main Authors: Thibault Mesplède, Mark A. Wainberg
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Viruses
Subjects:
HIV
integrase strand-transfer inhibitors
resistance
raltegravir
elvitegravir
dolutegravir
R263K
viral fitness
viral reservoirs
HIV eradication
Online Access:http://www.mdpi.com/1999-4915/7/7/2790

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http://www.mdpi.com/1999-4915/7/7/2790

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