Calcium Dobesilate Modulates PKCδ-NADPH Oxidase- MAPK-NF-κB Signaling Pathway to Reduce <i>CD14</i>, <i>TLR4</i>, and <i>MMP9</i> Expression during Monocyte-to-Macrophage Differentiation: Potential Therapeutic Implications for Atherosclerosis

Calcium Dobesilate Modulates PKCδ-NADPH Oxidase- MAPK-NF-κB Signaling Pathway to Reduce <i>CD14</i>, <i>TLR4</i>, and <i>MMP9</i> Expression during Monocyte-to-Macrophage Differentiation: Potential Therapeutic Implications for Atherosclerosis

Monocyte-to-macrophage differentiation results in the secretion of various inflammatory mediators and oxidative stress molecules necessary for atherosclerosis pathogenesis. Consequently, this differentiation represents a potential clinical target in atherosclerosis. Calcium dobesilate (CaD), an esta...

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Bibliographic Details
Main Authors: Florence Njau, Hermann Haller
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Antioxidants
Subjects:
atherosclerosis
calcium dobesilate
inflammation
monocyte-macrophage differentiation
oxidative stress
PKCδ
Online Access:https://www.mdpi.com/2076-3921/10/11/1798

Internet

https://www.mdpi.com/2076-3921/10/11/1798

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