A Novel Approach to Reducing Lung Metastasis in Osteosarcoma: Increasing Cell Stiffness with Carbenoxolone

A Novel Approach to Reducing Lung Metastasis in Osteosarcoma: Increasing Cell Stiffness with Carbenoxolone

Aim: Primary malignant bone tumor osteosarcoma can metastasize to the lung. Diminishing lung metastasis would positively affect the prognosis of patients. Our previous studies demonstrated that highly metastatic osteosarcoma cell lines are significantly softer than low-metastasis cell lines. We ther...

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Bibliographic Details
Main Authors: Kouji Kita, Kunihiro Asanuma, Takayuki Okamoto, Eiji Kawamoto, Koichi Nakamura, Tomohito Hagi, Tomoki Nakamura, Motomu Shimaoka, Akihiro Sudo
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Current Issues in Molecular Biology
Subjects:
metastasis
cell stiffness
atomic force microscopy
carbenoxolone
actin cytoskeleton
Online Access:https://www.mdpi.com/1467-3045/45/5/278

Internet

https://www.mdpi.com/1467-3045/45/5/278

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