LncRNA PKD1P6 modulates ovarian granulosa cell survival of hyperandrogenic polycystic ovary syndrome by targeting miR-135b-5p and inhibiting ERK1/2 signaling

LncRNA PKD1P6 modulates ovarian granulosa cell survival of hyperandrogenic polycystic ovary syndrome by targeting miR-135b-5p and inhibiting ERK1/2 signaling

Polycystic ovary syndrome (PCOS) is the most common and multifactorial endocrine disease among women of reproductive age. Aberrant folliculogenesis is a common pathological characteristic of PCOS, but the underlying molecular mechanism remains unclear. Emerging evidence indicated that aberrant expre...

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Bibliographic Details
Main Authors: Weidong Zhou, Yikai Lian, Jiahao Chen, Teng Zhang, Wenjing Zhang, Ruofan Huang, Mengjie Yang, Xiaohong Yan, Qionghua Chen
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:Heliyon
Subjects:
LncRNA PKD1P6
miR-135b-5p
Ovarian granulosa cell
MAPK pathway
Polycystic ovary syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024123523

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http://www.sciencedirect.com/science/article/pii/S2405844024123523

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