Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitors

Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitors

Summary: This study investigates the role of integrin β4 (ITGB4) and stemness-associated factor SOX2 in platinum resistance in lung squamous cell carcinoma (LUSC). The expression of SOX2 and ITGB4 is found to be high in all LUSC subtypes, but the impact of ITGB4 expression on overall patient surviva...

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Bibliographic Details
Main Authors: Linlin Guo, Atish Mohanty, Sharad Singhal, Saumya Srivastava, Arin Nam, Charles Warden, Sravani Ramisetty, Yate-Ching Yuan, Hyejin Cho, Xiwei Wu, Aimin Li, Manik Vohra, Srinivas Vinod Saladi, Deric Wheeler, Leonidas Arvanitis, Erminia Massarelli, Prakash Kulkarni, Yiming Zeng, Ravi Salgia
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Molecular biology
Cell biology
Cancer
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223013792

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http://www.sciencedirect.com/science/article/pii/S2589004223013792

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