Structural Insight into the Binding of TGIF1 to SIN3A PAH2 Domain through a C-Terminal Amphipathic Helix

Structural Insight into the Binding of TGIF1 to SIN3A PAH2 Domain through a C-Terminal Amphipathic Helix

TGIF1 is a transcriptional repressor playing crucial roles in human development and function and is associated with holoprosencephaly and various cancers. TGIF1-directed transcriptional repression of specific genes depends on the recruitment of corepressor SIN3A. However, to date, the exact region o...

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Bibliographic Details
Main Authors: Xiaoling He, Yao Nie, Heng Zhou, Rui Hu, Ying Li, Ting He, Jiang Zhu, Yunhuang Yang, Maili Liu
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
transcription repressor
intrinsically disordered protein
nuclear magnetic resonance (NMR)
molecular modeling
protein–protein interaction
Online Access:https://www.mdpi.com/1422-0067/22/23/12631

Internet

https://www.mdpi.com/1422-0067/22/23/12631

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