Cell cycle arrest and p53 prevent ON-target megabase-scale rearrangements induced by CRISPR-Cas9

Cell cycle arrest and p53 prevent ON-target megabase-scale rearrangements induced by CRISPR-Cas9

Abstract The CRISPR-Cas9 system has revolutionized our ability to precisely modify the genome and has led to gene editing in clinical applications. Comprehensive analysis of gene editing products at the targeted cut-site has revealed a complex spectrum of outcomes. ON-target genotoxicity is underest...

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Bibliographic Details
Main Authors: G. Cullot, J. Boutin, S. Fayet, F. Prat, J. Rosier, D. Cappellen, I. Lamrissi, P. Pennamen, J. Bouron, S. Amintas, C. Thibault, I. Moranvillier, E. Laharanne, J. P. Merlio, V. Guyonnet-Duperat, J. M. Blouin, E. Richard, S. Dabernat, F. Moreau-Gaudry, A. Bedel
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39632-w

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https://doi.org/10.1038/s41467-023-39632-w

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