Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

Severe falciparum malaria has substantially affected human evolution. Genetic association studies of patients with clinically defined severe malaria and matched population controls have helped characterise human genetic susceptibility to severe malaria, but phenotypic imprecision compromises discove...

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Bibliographic Details
Main Authors: James A Watson, Carolyne M Ndila, Sophie Uyoga, Alexander Macharia, Gideon Nyutu, Shebe Mohammed, Caroline Ngetsa, Neema Mturi, Norbert Peshu, Benjamin Tsofa, Kirk Rockett, Stije Leopold, Hugh Kingston, Elizabeth C George, Kathryn Maitland, Nicholas PJ Day, Arjen M Dondorp, Philip Bejon, Thomas N Williams, Chris C Holmes, Nicholas J White
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
severe malaria
GWAS
diagnosis
complete blood count
Online Access:https://elifesciences.org/articles/69698

Internet

https://elifesciences.org/articles/69698

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