G-Quadruplex DNA as a Macromolecular Target for Semi-Synthetic Isoflavones Bearing B-Ring Tosylation

G-Quadruplex DNA as a Macromolecular Target for Semi-Synthetic Isoflavones Bearing B-Ring Tosylation

Guanine-rich sequences of nucleic acids, including DNA and RNA, are known to fold into non-canonical structures named G-quadruplexes (G4s). Such arrangements of these macromolecular polymers are mainly located in telomeres and in promoter regions of oncogenes and, for this reason, they represent a p...

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Bibliographic Details
Main Authors: Giovanni Ribaudo, Margrate Anyanwu, Matteo Giannangeli, Erika Oselladore, Alberto Ongaro, Maurizio Memo, Alessandra Gianoncelli
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Macromol
Subjects:
DNA
G-quadruplex
flavonoids
ESI-MS
molecular modeling
molecular dynamics
Online Access:https://www.mdpi.com/2673-6209/4/3/33

Internet

https://www.mdpi.com/2673-6209/4/3/33

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