Supplementation of Saponins from Leaves of <i>Panax quinquefolius</i> Mitigates Cisplatin-Evoked Cardiotoxicity via Inhibiting Oxidative Stress-Associated Inflammation and Apoptosis in Mice

Supplementation of Saponins from Leaves of <i>Panax quinquefolius</i> Mitigates Cisplatin-Evoked Cardiotoxicity via Inhibiting Oxidative Stress-Associated Inflammation and Apoptosis in Mice

Background: Although kidney injury caused by cisplatin has attracted much attention, cisplatin-induced cardiotoxicity is elusive. Our previous studies have confirmed that saponins (ginsenosides) from <i>Panax quinquefolius</i> can effectively reduce acute renal injuries. Our current stud...

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Bibliographic Details
Main Authors: Jing-Jing Xing, Jin-Gang Hou, Ying Liu, Ruo-Bing Zhang, Shuang Jiang, Shen Ren, Ying-Ping Wang, Qiong Shen, Wei Li, Xin-Dian Li, Zi Wang
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Antioxidants
Subjects:
ginsenosides
cisplatin
cardiotoxicity
PI3K/Akt/GSK-3β
oxidative stress
inflammation
apoptosis
Online Access:https://www.mdpi.com/2076-3921/8/9/347

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https://www.mdpi.com/2076-3921/8/9/347

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