Store‐operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease

Store‐operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease

Abstract Inflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune responses. Using mass cytometry (CyTOF) to analyze the immune cell composition in the lamina propria (LP) of patients with ulcerative colitis (UC) and Crohn's disease (CD), we observed an enrichment of...

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Bibliographic Details
Main Authors: Marilena Letizia, Yin‐Hu Wang, Ulrike Kaufmann, Lorenz Gerbeth, Annegret Sand, Max Brunkhorst, Patrick Weidner, Jörn Felix Ziegler, Chotima Böttcher, Stephan Schlickeiser, Camila Fernández, Megumi Yamashita, Kenneth Stauderman, Katherine Sun, Désirée Kunkel, Murali Prakriya, IBDome Researchers, Ashley Sanders, Britta Siegmund, Stefan Feske, Carl Weidinger
Format: Article
Language:English
Published: Springer Nature 2022-08-01
Series:EMBO Molecular Medicine
Subjects:
Crohn's disease
mass cytometry
store‐operated calcium entry (SOCE)
T cell transfer models of colitis
ulcerative colitis
Online Access:https://doi.org/10.15252/emmm.202215687

Internet

https://doi.org/10.15252/emmm.202215687

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