Thrombospondin-1 overexpression stimulates loss of Smad4 and accelerates malignant behavior via TGF-β signal activation in pancreatic ductal adenocarcinoma

Thrombospondin-1 overexpression stimulates loss of Smad4 and accelerates malignant behavior via TGF-β signal activation in pancreatic ductal adenocarcinoma

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma and cancer-associated fibroblasts (CAFs) provide a favorable tumor microenvironment. Smad4 is known as tumor suppressor in several types of cancers including PDAC, and loss of Smad4 triggers accelerated cell in...

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Bibliographic Details
Main Authors: Kazuki Matsumura, Hiromitsu Hayashi, Norio Uemura, Yoko Ogata, Liu Zhao, Hiroki Sato, Yuta Shiraishi, Hideyuki Kuroki, Fumimasa Kitamura, Takayoshi Kaida, Takaaki Higashi, Shigeki Nakagawa, Kosuke Mima, Katsunori Imai, Yo-ichi Yamashita, Hideo Baba
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Translational Oncology
Subjects:
Cancer associated fibroblasts
Pancreatic ductal adenocarcinoma
Smad4
Stiffness
Thrombospondin-1
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523322001929

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http://www.sciencedirect.com/science/article/pii/S1936523322001929

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