Sonic Hedgehog reduces inflammatory response, decreases blood-spinal cord barrier permeability, and improves locomotor function recovery in an acute spinal cord injury rat model

Sonic Hedgehog reduces inflammatory response, decreases blood-spinal cord barrier permeability, and improves locomotor function recovery in an acute spinal cord injury rat model

Abstract Background Sonic Hedgehog (Shh), extensively researched for its role in early neurogenesis and brain development, has recently been recognized for its neuroprotective potential following neuronal injuries. This study examines the immediate impact of early administered Shh on the local infla...

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Bibliographic Details
Main Authors: Mohamed Tail, Hao Zhang, Guoli Zheng, Anna-Kathrin Harms, Maryam Hatami, Thomas Skutella, Karl Kiening, Andreas Unterberg, Klaus Zweckberger, Alexander Younsi
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Journal of Inflammation
Subjects:
SCI
BSCB
Spinal cord injury
Sonic Hedgehog
Inflammation
Online Access:https://doi.org/10.1186/s12950-024-00404-y

Internet

https://doi.org/10.1186/s12950-024-00404-y

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