Deep flanking sequence engineering for efficient promoter design using DeepSEED

Abstract Designing promoters with desirable properties is essential in synthetic biology. Human experts are skilled at identifying strong explicit patterns in small samples, while deep learning models excel at detecting implicit weak patterns in large datasets. Biologists have described the sequence...

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Bibliographic Details
Main Authors: Pengcheng Zhang, Haochen Wang, Hanwen Xu, Lei Wei, Liyang Liu, Zhirui Hu, Xiaowo Wang
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41899-y