Osteoblasts Promote Prostate Cancer Cell Proliferation Through Androgen Receptor Independent Mechanisms

Osteoblasts Promote Prostate Cancer Cell Proliferation Through Androgen Receptor Independent Mechanisms

Patients with metastatic prostate cancer frequently develop bone metastases that elicit significant skeletal morbidity and increased mortality. The high tropism of prostate cancer cells for bone and their tendency to induce the osteoblastic-like phenotype are a result of a complex interplay between...

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Bibliographic Details
Main Authors: Giulia Ribelli, Sonia Simonetti, Michele Iuliani, Elisabetta Rossi, Bruno Vincenzi, Giuseppe Tonini, Francesco Pantano, Daniele Santini
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Oncology
Subjects:
castration resistance prostate cancer
bone microenvironment
androgen receptor
osteoblasts
matrix metalloproteinase-1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.789885/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.789885/full

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