Recovering Actives in Multi-Antitarget and Target Design of Analogs of the Myosin II Inhibitor Blebbistatin

In multitarget drug design, it is critical to identify active and inactive compounds against a variety of targets and antitargets. Multitarget strategies thus test the limits of available technology, be that in screening large databases of compounds vs. a large number of targets, or in using in sili...

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Bibliographic Details
Main Authors: Bart I. Roman, Rita C. Guedes, Christian V. Stevens, Alfonso T. García-Sosa
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Chemistry
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00179/full